Review of Evidence on Alcohol and Health (2025)

Chapter: Appendix D: AMSTAR-2 Tables

Previous Chapter: Appendix C: Timeline of Screening for Eligibility
Suggested Citation: "Appendix D: AMSTAR-2 Tables." National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. doi: 10.17226/28582.

Appendix D

AMSTAR-2 Tables

TABLE D-1 AMSTAR-2 Evaluation for All-Cause Mortality Systematic Reviews with or without Meta-Analyses Published between 2019 and 2024

AMSTAR Question Study (Author, Year)
van de Luitgaarden et al., 2022 Zhao et al., 2023 Estruch and Hendriks 2022 Boushey et al., 2020 English et al., 2021 Marcos et al., 2021
Did the research questions and inclusion criteria for the review include ALL the components of PICO? yes yes yes yes yes yes
Did the report of the review contain an explicit statement that the review methods were established prior to the conduct of the review and did the report justify any significant deviations from the protocol? yes yes no yes yes no
Suggested Citation: "Appendix D: AMSTAR-2 Tables." National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. doi: 10.17226/28582.
AMSTAR Question Study (Author, Year)
van de Luitgaarden et al., 2022 Zhao et al., 2023 Estruch and Hendriks 2022 Boushey et al., 2020 English et al., 2021 Marcos et al., 2021
Did the review authors explain their selection of the study designs for inclusion in the review? yes yes yes yes yes yes
Did the authors use a comprehensive literature search strategy? yes yes yes yes yes yes
Did the review authors perform study selection in duplicate? yes yes yes yes yes not known
Did the review authors perform data extraction in duplicate? yes yes yes yes yes not known
Did the review authors provide a list of excluded studies and justify the exclusions? partial no partially yes n/a no
Did the review authors describe the included studies in adequate detail? yes yes yes yes yes yes
Did the review authors use a satisfactory technique for assessing the risk of bias (RoB) in individual studies that were included in the review? yes n/a no yes yes not known
Did the review authors report on the sources of funding for the studies included in the review? no yes yes yes yes yes
Suggested Citation: "Appendix D: AMSTAR-2 Tables." National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. doi: 10.17226/28582.
AMSTAR Question Study (Author, Year)
van de Luitgaarden et al., 2022 Zhao et al., 2023 Estruch and Hendriks 2022 Boushey et al., 2020 English et al., 2021 Marcos et al., 2021
If meta-analysis was performed did the review authors use appropriate methods for statistical combination of results? n/a yes n/a n/a n/a n/a
Did the review authors account for RoB in individual studies when interpreting/discussing the results of the review? partial yes partially yes yes no
Did the review authors provide a satisfactory explanation for, and discussion of, any heterogeneity observed in the results of the review? yes yes yes yes yes yes
If they performed quantitative synthesis did the review authors carry out an adequate investigation of publication bias (small study bias) and discuss its likely impact on the results of the review? n/a yes n/a n/a n/a n/a
Did the review authors report any potential sources of conflict of interest, including any funding they received for conducting the review? yes yes yes yes yes yes
OVERALL “QUALITY” moderate moderate low high high critically low

NOTES: n/a = not applicable; PICO = population, intervention, comparator, outcome; RoB = risk of bias.

Suggested Citation: "Appendix D: AMSTAR-2 Tables." National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. doi: 10.17226/28582.

TABLE D-2 AMSTAR-2 Evaluation for Weight Change Systematic Reviews with or without Meta-Analyses Published Between 2019 and 2024

AMSTAR Question Study (Author, Year)
Golzarand et al., 2022 Siegmann et al., 2022
Did the research questions and inclusion criteria for the review include ALL the components of PICO? yes yes
Did the report of the review contain an explicit statement that the review methods were established prior to the conduct of the review and did the report justify any significant deviations from the protocol? yes no
Did the review authors explain their selection of the study designs for inclusion in the review? yes yes
Did the authors use a comprehensive literature search strategy? yes yes
Did the review authors perform study selection in duplicate? yes yes
Did the review authors perform data extraction in duplicate? unknown yes
Did the review authors provide a list of excluded studies and justify the exclusions? no yes
Did the review authors describe the included studies in adequate detail? yes yes
Did the review authors use a satisfactory technique for assessing the risk of bias (RoB) in individual studies that were included in the review? yes yes
Did the review authors report on the sources of funding for the studies included in the review? no no
If meta-analysis was performed did the review authors use appropriate methods for statistical combination of results? n/a yes
Suggested Citation: "Appendix D: AMSTAR-2 Tables." National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. doi: 10.17226/28582.
AMSTAR Question Study (Author, Year)
Golzarand et al., 2022 Siegmann et al., 2022
Did the review authors account for RoB in individual studies when interpreting/discussing the results of the review? no yes (but did not include RoB score for each study, just that it was accounted for)
Did the review authors provide a satisfactory explanation for, and discussion of, any heterogeneity observed in the results of the review? yes yes
If they performed quantitative synthesis did the review authors carry out an adequate investigation of publication bias (small study bias) and discuss its likely impact on the results of the review? yes yes
Did the review authors report any potential sources of conflict of interest, including any funding they received for conducting the review? yes yes
OVERALL “QUALITY” low low

NOTES: n/a = not applicable; PICO = population, intervention, comparator, outcome; RoB = risk of bias.

Suggested Citation: "Appendix D: AMSTAR-2 Tables." National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. doi: 10.17226/28582.

TABLE D-3 AMSTAR-2 Evaluation for Cancer Systematic Reviews with or without Meta-Analyses Published Between 2019 and 2024

AMSTAR Question Study (Author, Year)
Breau and Ellis, 2020 Burton et al., 2024 Estruch and Hendriks, 2022 Fakhri et al., 2022 Hua et al., 2023 Jun et al., 2023 Levesque et al., 2023 Luceron-Lucas-Torres et al., 2023 McNabb et al., 2020
Did the research questions and inclusion criteria for the review include ALL the components of PICO? yes yes yes yes yes yes yes yes yes
Did the report of the review contain an explicit statement that the review methods were established prior to the conduct of the review and did the report justify any significant deviations from the protocol? no mention of protocol yes yes no mention of protocol yes yes yes yes no mention of protocol
Did the review authors explain their selection of the study designs for inclusion in the review? yes yes yes yes yes yes yes yes yes
Did the authors use a comprehensive literature search strategy? yes yes yes no yes yes yes yes n/a
Suggested Citation: "Appendix D: AMSTAR-2 Tables." National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. doi: 10.17226/28582.
Did the review authors perform study selection in duplicate? yes yes yes not stated yes yes yes yes n/a
Did the review authors perform data extraction in duplicate? yes No yes not stated yes yes yes yes n/a
Did the review authors provide a list of excluded studies and justify the exclusions? Partial Yes partial no partial partial partial yes n/a
Did the review authors describe the included studies in adequate detail? yes yes yes yes yes yes yes yes yes
Did the review authors use a satisfactory technique for assessing the risk of bias (RoB) in individual studies that were included in the review? yes yes no no yes yes yes yes not stated
Did the review authors report on the sources of funding for the studies included in the review? No No no no no no no no no
If meta-analysis was performed did the review authors use appropriate methods for statistical combination of results? yes yes n/a n/a yes yes n/a yes yes
Suggested Citation: "Appendix D: AMSTAR-2 Tables." National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. doi: 10.17226/28582.
AMSTAR Question Study (Author, Year)
Breau and Ellis, 2020 Burton et al., 2024 Estruch and Hendriks, 2022 Fakhri et al., 2022 Hua et al., 2023 Jun et al., 2023 Levesque et al., 2023 Luceron-Lucas-Torres et al., 2023 McNabb et al., 2020
Did the review authors provide a satisfactory explanation for, and discussion of, any heterogeneity observed in the results of the review? yes yes yes no yes yes yes yes yes
If they performed quantitative synthesis did the review authors carry out an adequate investigation of publication bias (small study bias) and discuss its likely impact on the results of the review? No Yes n/a n/a yes yes n/a yes n/a
Did the review authors report any potential sources of conflict of interest, including any funding they received for conducting the review? yes yes yes yes yes yes yes yes yes
OVERALL “QUALITY” critically low high low critically low high moderate moderate high unknown

NOTES: n/a = not applicable; PICO = population, intervention, comparator, outcome; RoB = risk of bias.

Suggested Citation: "Appendix D: AMSTAR-2 Tables." National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. doi: 10.17226/28582.
AMSTAR Question Study (Author, Year)
Papadimitriou et al., 2021 Poorolajal et al., 2021 Shin et al., 2023 Sun et al., 2023 Veettil et al., 2021 Wiggs et al., 2021 Xu et al., 2019 Zhong et al., 2022
Did the research questions and inclusion criteria for the review include ALL the components of PICO? yes yes yes yes yes yes yes yes
Did the report of the review contain an explicit statement that the review methods were established prior to the conduct of the review and did the report justify any significant deviations from the protocol? no mention of protocol yes yes yes yes no mention of protocol yes yes
Did the review authors explain their selection of the study designs for inclusion in the review? yes yes yes yes yes yes yes yes
Did the authors use a comprehensive literature search strategy? yes yes yes yes yes yes yes yes
Did the review authors perform study selection in duplicate? yes yes yes yes yes yes yes yes
Did the review authors perform data extraction in duplicate? yes yes yes yes yes yes yes yes
Did the review authors provide a list of excluded studies and justify the exclusions? yes partial partial partial yes partial partial yes
Did the review authors describe the included studies in adequate detail? yes yes yes yes yes yes yes yes
Did the review authors use a satisfactory technique for assessing the risk of bias (RoB) in individual studies that were included in the review? yes yes yes yes yes no yes yes
Suggested Citation: "Appendix D: AMSTAR-2 Tables." National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. doi: 10.17226/28582.
AMSTAR Question Study (Author, Year)
Papadimitriou et al., 2021 Poorolajal et al., 2021 Shin et al., 2023 Sun et al., 2023 Veettil et al., 2021 Wiggs et al., 2021 Xu et al., 2019 Zhong et al., 2022
If meta-analysis was performed did the review authors use appropriate methods for statistical combination of results? n/a yes yes yes n/a n/a yes n/a
Did the review authors account for RoB in individual studies when interpreting/discussing the results of the review? yes yes yes yes yes partial yes yes
Did the review authors provide a satisfactory explanation for, and discussion of, any heterogeneity observed in the results of the review? yes yes yes yes yes yes yes yes
If they performed quantitative synthesis did the review authors carry out an adequate investigation of publication bias (small study bias) and discuss its likely impact on the results of the review? yes yes yes yes yes n/a yes n/a
Did the review authors report any potential sources of conflict of interest, including any funding they received for conducting the review? yes yes yes yes yes yes yes yes
OVERALL “QUALITY” low moderate moderate high high critically low high high

NOTES: n/a = not applicable; PICO = population, intervention, comparator, outcome; RoB = risk of bias.

Suggested Citation: "Appendix D: AMSTAR-2 Tables." National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. doi: 10.17226/28582.

TABLE D-4 AMSTAR-2 Evaluation for Cardiovascular Disease Systematic Reviews with or without Meta-Analyses Published Between 2019 and 2024

AMSTAR Question Study (Author, Year)
Aljuraiban et al., 2024 Arafa et al., 2023 Del Giorno et al., 2022 Giannopoulos et al., 2022 Hwang et al., 2021 Jung et al., 2020 Krittanawong et al., 2022 Levesque et al., 2023 Liu et al., 2020 Marcos et al., 2021
Did the research questions and inclusion criteria for the review include ALL the components of PICO? yes yes yes yes yes yes yes yes yes yes
Did the report of the review contain an explicit statement that the review methods were established prior to the conduct of the review and did the report justify any significant deviations from the protocol? yes yes yes yes yes no no yes no no
Did the review authors explain their selection of the study designs for inclusion in the review? yes yes yes yes yes yes yes yes yes yes
Did the authors use a comprehensive literature search strategy? yes yes yes yes yes yes yes yes yes yes
Suggested Citation: "Appendix D: AMSTAR-2 Tables." National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. doi: 10.17226/28582.
AMSTAR Question Study (Author, Year)
Aljuraiban et al., 2024 Arafa et al., 2023 Del Giorno et al., 2022 Giannopoulos et al., 2022 Hwang et al., 2021 Jung et al., 2020 Krittanawong et al., 2022 Levesque et al., 2023 Liu et al., 2020 Marcos et al., 2021
Did the review authors perform study selection in duplicate? yes not stated yes yes yes yes not stated yes yes not stated
Did the review authors perform data extraction in duplicate? yes not stated yes yes yes yes not stated yes yes not stated
Did the review authors provide a list of excluded studies and justify the exclusions? yes partial partial partial yes yes no partial yes no
Did the review authors describe the included studies in adequate detail? yes yes yes yes yes yes yes yes yes yes
Did the review authors use a satisfactory technique for assessing the risk of bias (RoB) in individual studies that were included in the review? yes yes yes yes yes yes no yes yes no
Suggested Citation: "Appendix D: AMSTAR-2 Tables." National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. doi: 10.17226/28582.
Did the review authors report on the sources of funding for the studies included in the review? yes no no no no no no no no yes
If meta-analysis was performed did the review authors use appropriate methods for statistical combination of results? n/a yes n/a yes n/a yes n/a n/a yes n/a
Did the review authors account for RoB in individual studies when interpreting/discussing the results of the review? yes yes no yes yes yes no yes yes no
Did the review authors provide a satisfactory explanation for, and discussion of, any heterogeneity observed in the results of the review? yes yes yes yes yes yes yes yes yes yes
Suggested Citation: "Appendix D: AMSTAR-2 Tables." National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. doi: 10.17226/28582.
AMSTAR Question Study (Author, Year)
Aljuraiban et al., 2024 Arafa et al., 2023 Del Giorno et al., 2022 Giannopoulos et al., 2022 Hwang et al., 2021 Jung et al., 2020 Krittanawong et al., 2022 Levesque et al., 2023 Liu et al., 2020 Marcos et al., 2021
If they performed quantitative synthesis did the review authors carry out an adequate investigation of publication bias (small study bias) and discuss its likely impact on the results of the review? n/a yes n/a yes n/a yes n/a n/a yes n/a
Did the review authors report any potential sources of conflict of interest, including any funding they received for conducting the review? yes yes yes yes yes yes yes yes yes yes
OVERALL “QUALITY” high moder ate low moderate high low critically low moderate low critically low

NOTES: n/a = not applicable; PICO = population, intervention, comparator, outcome; RoB = risk of bias.

Suggested Citation: "Appendix D: AMSTAR-2 Tables." National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. doi: 10.17226/28582.
AMSTAR Question Study (Author, Year)
Siagian et al., 2023 Spaggiari et al., 2020 Tasnim et al., 2020 van de Luitgaarden et al., 2022 Wilkens et al., 2022 Yang et al., 2022 Yoon et al., 2020 Zhang et al., 2021 Zhong et al., 2022
Did the research questions and inclusion criteria for the review include ALL the components of PICO? yes yes yes yes yes yes yes yes yes
Did the report of the review contain an explicit statement that the review methods were established prior to the conduct of the review and did the report justify any significant deviations from the protocol? yes yes yes yes yes no no no yes
Did the review authors explain their selection of the study designs for inclusion in the review? yes yes yes yes yes yes yes yes yes
Did the authors use a comprehensive literature search strategy? yes yes yes yes yes yes yes yes yes
Did the review authors perform study selection in duplicate? yes yes yes yes yes yes yes yes yes
Suggested Citation: "Appendix D: AMSTAR-2 Tables." National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. doi: 10.17226/28582.
AMSTAR Question Study (Author, Year)
Siagian et al., 2023 Spaggiari et al., 2020 Tasnim et al., 2020 van de Luitgaarden et al., 2022 Wilkens et al., 2022 Yang et al., 2022 Yoon et al., 2020 Zhang et al., 2021 Zhong et al., 2022
Did the review authors perform data extraction in duplicate? yes yes yes yes yes yes yes yes yes
Did the review authors provide a list of excluded studies and justify the exclusions? partial yes yes partial partial partial partial partial yes
Did the review authors describe the included studies in adequate detail? yes yes yes yes yes yes yes yes yes
Did the review authors use a satisfactory technique for assessing the risk of bias (RoB) in individual studies that were included in the review? yes yes yes yes yes yes yes yes yes
Did the review authors report on the sources of funding for the studies included in the review? no no yes no no no no no no
If meta-analysis was performed did the review authors use appropriate methods for statistical combination of results? yes yes yes n/a n/a yes yes yes n/a
Suggested Citation: "Appendix D: AMSTAR-2 Tables." National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. doi: 10.17226/28582.
Did the review authors account for RoB in individual studies when interpreting/discussing the results of the review? no yes yes yes yes yes yes no yes
Did the review authors provide a satisfactory explanation for, and discussion of, any heterogeneity observed in the results of the review? yes yes yes yes yes yes yes yes yes
If they performed quantitative synthesis did the review authors carry out an adequate investigation of publication bias (small study bias) and discuss its likely impact on the results of the review? no yes yes n/a n/a yes yes yes yes
Did the review authors report any potential sources of conflict of interest, including any funding they received for conducting the review? yes yes yes yes yes yes yes yes yes
OVERALL “QUALITY” critically low high high moderate moderate low low critically low high

NOTES: n/a = not applicable; PICO = population, intervention, comparator, outcome; RoB = risk of bias.

Suggested Citation: "Appendix D: AMSTAR-2 Tables." National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. doi: 10.17226/28582.

TABLE D-5 AMSTAR-2 Evaluation for Neurocognitive Health Systematic Reviews with or without Meta-Analyses Published Between 2019 and 2024

AMSTAR Question Study (Author, Year)
Brennan et al., 2020 Jones et al., 2024 Kilian et al., 2023 Lao et al., 2021 Luceron-Lucas-Torres et al., 2022 Porras-Garcia et al., 2023 Ran et al., 2021 Visontay et al., 2022 Wiegmann et al., 2020 Xie and Feng, 2022
Did the research questions and inclusion criteria for the review include ALL the components of PICO? yes yes yes yes yes yes yes yes yes yes
Did the report of the review contain an explicit statement that the review methods were established prior to the conduct of the review and did the report justify any significant deviations from the protocol? yes yes yes yes yes yes yes yes No partial
Did the review authors explain their selection of the study designs for inclusion in the review? yes yes yes yes yes yes yes yes yes yes
Did the authors use a comprehensive literature search strategy? yes yes yes yes yes yes yes yes yes yes
Did the review authors perform study selection in duplicate? yes yes yes yes yes yes yes yes not determined yes
Suggested Citation: "Appendix D: AMSTAR-2 Tables." National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. doi: 10.17226/28582.
Did the review authors perform data extraction in duplicate? yes yes yes yes yes yes yes yes not determined yes
Did the review authors provide a list of excluded studies and justify the exclusions? yes yes yes yes yes yes yes yes no yes
Did the review authors describe the included studies in adequate detail? yes yes yes yes yes yes yes yes yes yes
Did the review authors use a satisfactory technique for assessing the risk of bias (RoB) in individual studies that were included in the review? yes yes yes yes yes yes yes yes not performed yes
Did the review authors report on the sources of funding for the studies included in the review? yes no no no no no no no no no
If meta-analysis was performed did the review authors use appropriate methods for statistical combination of results? n/a n/a n/a yes yes n/a yes n/a n/a yes
Did the review authors account for RoB in individual studies when interpreting/discussing the results of the review? yes no yes yes yes yes yes yes No yes
Suggested Citation: "Appendix D: AMSTAR-2 Tables." National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. doi: 10.17226/28582.
AMSTAR Question Study (Author, Year)
Brennan et al., 2020 Jones et al., 2024 Kilian et al., 2023 Lao et al., 2021 Luceron-Lucas-Torres et al., 2022 Porras-Garcia et al., 2023 Ran et al., 2021 Visontay et al., 2022 Wiegmann et al., 2020 Xie and Feng, 2022
Did the review authors provide a satisfactory explanation for, and discussion of, any heterogeneity observed in the results of the review? yes yes yes yes yes yes yes yes yes yes
If they performed quantitative synthesis did the review authors carry out an adequate investigation of publication bias (small study bias) and discuss its likely impact on the results of the review? yes n/a n/a Yes yes n/a yes n/a n/a yes
Did the review authors report any potential sources of conflict of interest, including any funding they received for conducting the review? yes yes yes yes yes yes yes yes yes yes
OVERALL “QUALITY” high low high high high high high high critically low high

NOTES: n/a = not applicable; PICO = population, intervention, comparator, outcome; RoB = risk of bias.

Suggested Citation: "Appendix D: AMSTAR-2 Tables." National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. doi: 10.17226/28582.

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Suggested Citation: "Appendix D: AMSTAR-2 Tables." National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. doi: 10.17226/28582.

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Suggested Citation: "Appendix D: AMSTAR-2 Tables." National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. doi: 10.17226/28582.

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Suggested Citation: "Appendix D: AMSTAR-2 Tables." National Academies of Sciences, Engineering, and Medicine. 2025. Review of Evidence on Alcohol and Health. Washington, DC: The National Academies Press. doi: 10.17226/28582.
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