Machine Learning for Safety-Critical Applications: Opportunities, Challenges, and a Research Agenda (2025)

Chapter: 1 Engineering Safety-Critical Systems in the Age of Machine Learning

Previous Chapter: Summary
Suggested Citation: "1 Engineering Safety-Critical Systems in the Age of Machine Learning." National Academies of Sciences, Engineering, and Medicine. 2025. Machine Learning for Safety-Critical Applications: Opportunities, Challenges, and a Research Agenda. Washington, DC: The National Academies Press. doi: 10.17226/27970.
Page 11
Suggested Citation: "1 Engineering Safety-Critical Systems in the Age of Machine Learning." National Academies of Sciences, Engineering, and Medicine. 2025. Machine Learning for Safety-Critical Applications: Opportunities, Challenges, and a Research Agenda. Washington, DC: The National Academies Press. doi: 10.17226/27970.
Page 12
Suggested Citation: "1 Engineering Safety-Critical Systems in the Age of Machine Learning." National Academies of Sciences, Engineering, and Medicine. 2025. Machine Learning for Safety-Critical Applications: Opportunities, Challenges, and a Research Agenda. Washington, DC: The National Academies Press. doi: 10.17226/27970.
Page 13
Suggested Citation: "1 Engineering Safety-Critical Systems in the Age of Machine Learning." National Academies of Sciences, Engineering, and Medicine. 2025. Machine Learning for Safety-Critical Applications: Opportunities, Challenges, and a Research Agenda. Washington, DC: The National Academies Press. doi: 10.17226/27970.
Page 14
Suggested Citation: "1 Engineering Safety-Critical Systems in the Age of Machine Learning." National Academies of Sciences, Engineering, and Medicine. 2025. Machine Learning for Safety-Critical Applications: Opportunities, Challenges, and a Research Agenda. Washington, DC: The National Academies Press. doi: 10.17226/27970.
Page 15
Suggested Citation: "1 Engineering Safety-Critical Systems in the Age of Machine Learning." National Academies of Sciences, Engineering, and Medicine. 2025. Machine Learning for Safety-Critical Applications: Opportunities, Challenges, and a Research Agenda. Washington, DC: The National Academies Press. doi: 10.17226/27970.
Page 16
Suggested Citation: "1 Engineering Safety-Critical Systems in the Age of Machine Learning." National Academies of Sciences, Engineering, and Medicine. 2025. Machine Learning for Safety-Critical Applications: Opportunities, Challenges, and a Research Agenda. Washington, DC: The National Academies Press. doi: 10.17226/27970.
Page 17
Suggested Citation: "1 Engineering Safety-Critical Systems in the Age of Machine Learning." National Academies of Sciences, Engineering, and Medicine. 2025. Machine Learning for Safety-Critical Applications: Opportunities, Challenges, and a Research Agenda. Washington, DC: The National Academies Press. doi: 10.17226/27970.
Page 18
Suggested Citation: "1 Engineering Safety-Critical Systems in the Age of Machine Learning." National Academies of Sciences, Engineering, and Medicine. 2025. Machine Learning for Safety-Critical Applications: Opportunities, Challenges, and a Research Agenda. Washington, DC: The National Academies Press. doi: 10.17226/27970.
Page 19
Suggested Citation: "1 Engineering Safety-Critical Systems in the Age of Machine Learning." National Academies of Sciences, Engineering, and Medicine. 2025. Machine Learning for Safety-Critical Applications: Opportunities, Challenges, and a Research Agenda. Washington, DC: The National Academies Press. doi: 10.17226/27970.
Page 20
Suggested Citation: "1 Engineering Safety-Critical Systems in the Age of Machine Learning." National Academies of Sciences, Engineering, and Medicine. 2025. Machine Learning for Safety-Critical Applications: Opportunities, Challenges, and a Research Agenda. Washington, DC: The National Academies Press. doi: 10.17226/27970.
Page 21
Suggested Citation: "1 Engineering Safety-Critical Systems in the Age of Machine Learning." National Academies of Sciences, Engineering, and Medicine. 2025. Machine Learning for Safety-Critical Applications: Opportunities, Challenges, and a Research Agenda. Washington, DC: The National Academies Press. doi: 10.17226/27970.
Page 22
Suggested Citation: "1 Engineering Safety-Critical Systems in the Age of Machine Learning." National Academies of Sciences, Engineering, and Medicine. 2025. Machine Learning for Safety-Critical Applications: Opportunities, Challenges, and a Research Agenda. Washington, DC: The National Academies Press. doi: 10.17226/27970.
Page 23
Suggested Citation: "1 Engineering Safety-Critical Systems in the Age of Machine Learning." National Academies of Sciences, Engineering, and Medicine. 2025. Machine Learning for Safety-Critical Applications: Opportunities, Challenges, and a Research Agenda. Washington, DC: The National Academies Press. doi: 10.17226/27970.
Page 24
Suggested Citation: "1 Engineering Safety-Critical Systems in the Age of Machine Learning." National Academies of Sciences, Engineering, and Medicine. 2025. Machine Learning for Safety-Critical Applications: Opportunities, Challenges, and a Research Agenda. Washington, DC: The National Academies Press. doi: 10.17226/27970.
Page 25
Suggested Citation: "1 Engineering Safety-Critical Systems in the Age of Machine Learning." National Academies of Sciences, Engineering, and Medicine. 2025. Machine Learning for Safety-Critical Applications: Opportunities, Challenges, and a Research Agenda. Washington, DC: The National Academies Press. doi: 10.17226/27970.
Page 26
Suggested Citation: "1 Engineering Safety-Critical Systems in the Age of Machine Learning." National Academies of Sciences, Engineering, and Medicine. 2025. Machine Learning for Safety-Critical Applications: Opportunities, Challenges, and a Research Agenda. Washington, DC: The National Academies Press. doi: 10.17226/27970.
Page 27
Next Chapter: 2 State of the Art, Promises, and Risks of Machine Learning
Subscribe to Email from the National Academies
Keep up with all of the activities, publications, and events by subscribing to free updates by email.