Previous Chapter: 3 Potential Solutions and Considerations for Implementation
Suggested Citation: "References." National Academies of Sciences, Engineering, and Medicine. 2025. Disseminating In Silico and Computational Biological Research: Navigating Benefits and Risks: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/29174.

References

Baek, M., F. DiMaio, I. Anishchenko, J. Dauparas, S. Ovchinnikov, G. R. Lee, J. Wang, Q. Cong, L. N. Kinch, R. D. Schaeffer, C. Millán, H. Park, C. Adams, C. R. Glassman, A. DeGiovanni, J. H. Pereira, A. V. Rodrigues, A. A. van Dijk, A. C. Ebrecht, D. J. Opperman, T. Sagmeister, C. Buhlheller, T. Pavkov-Keller, M. K. Rathinaswamy, U. Dalwadi, C. K. Yip, J. E. Burke, K. C. Garcia, N. V. Grishin, P. D. Adams, R. J. Read, and D. Baker. 2021. “Accurate prediction of protein structures and interactions using a three-track neural network.” Science 373 (6557): 871–876. https://doi.org/10.1126/science.abj8754.

Carter, S. R., N. E. Wheeler, C. R. Isaac, and J. Yassif. 2024. Developing Guardrails for AI Biodesign Tools. Washington, DC: Nuclear Threat Initiative. https://www.nti.org/wp-content/uploads/2024/11/NTIBio_Paper_Developing-Guardrails-for-AI-Biodesign-Tools_FINAL.pdf (accessed July 18, 2025).

Chen, J., W. Zhang, Y. Li, C. Liu, T. Dong, H. Chen, C. Wu, J. Su, B. Li, W. Zhang, B. Hu, J. Jia, C.-B. Ma, Y. Zhu, X. He, A. Li, K. Pan, H. Lin, Z. Guo, C. Li, L. Zhang, H. Yan, P. Zhou, W. Peng, and Z.-L. Shi. 2025. “Bat-infecting merbecovirus HKU5-CoV lineage 2 can use human ACE2 as a cell entry receptor.” Cell 188 (6): 1729–1742. https://doi.org/10.1016/j.cell.2025.01.042.

Dauparas, J., I. Anishchenko, N. Bennett, H. Bai, R. J. Ragotte, L. F. Milles, B. I. M. Wicky, A. Courbet, R. J. de Haas, N. Bethel, P. J. Y. Leung, T. F. Huddy, S. Pellock, D. Tischer, F. Chan, B. Koepnick, H. Nguyen, A. Kang, B. Sankaran, A. K. Bera, N. P. King, and D. Baker. 2022. “Robust deep learning–based protein sequence design using ProteinMPNN.” Science 378 (6615): 49–56. https://doi.org/10.1126/science.add2187.

Fast Track Action Committee on Synthetic Nucleic Acid Procurement Screening. Framework for Nucleic Acid Synthesis Screening. 2024. https://www.whitehouse.gov/wp-content/uploads/2024/04/Nucleic-Acid_Synthesis_Screening_Framework.pdf (accessed July 16, 2025).

Hayes, T., R. Rao, H. Akin, N. J. Sofroniew, D. Oktay, Z. Lin, R. Verkuil, V. Q. Tran, J. Deaton, M. Wiggert, R. Badkundri, I. Shafkat, J. Gong, A. Derry, R. S. Molina, N. Thomas, Y. A. Khan, C. Mishra, C. Kim, L. J. Bartie, M. Nemeth, P. D. Hsu, T. Sercu, S. Candido, and A. Rives. 2025. “Simulating 500 million years of evolution with a language model.” Science 387 (6736): 850–858. https://doi.org/10.1126/science.ads0018.

Institute of Medicine, National Academy of Sciences, and National Academy of Engineering. 1982. Scientific Communication and National Security. Washington, DC: National Academy Press. https://doi.org/10.17226/253.

Institute of Medicine and National Research Council. 2015. Potential Risks and Benefits of Gain-of-Function Research: Summary of a Workshop. Washington, DC: The National Academies Press. https://doi.org/10.17226/21666.

Suggested Citation: "References." National Academies of Sciences, Engineering, and Medicine. 2025. Disseminating In Silico and Computational Biological Research: Navigating Benefits and Risks: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/29174.

Jumper, J., R. Evans, A. Pritzel, T. Green, M. Figurnov, O. Ronneberger, K. Tunyasuvunakool, R. Bates, A. Žídek, A. Potapenko, A. Bridgland, C. Meyer, S. A. A. Kohl, A. J. Ballard, A. Cowie, B. Romera-Paredes, S. Nikolov, R. Jain, J. Adler, T. Back, S. Petersen, D. Reiman, E. Clancy, M. Zielinski, M. Steinegger, M. Pacholska, T. Berghammer, S. Bodenstein, D. Silver, O. Vinyals, A. W. Senior, K. Kavukcuoglu, P. Kohli, and D. Hassabis. 2021. “Highly accurate protein structure prediction with AlphaFold.” Nature 596 (7873): 583–589. https://doi.org/10.1038/s41586-021-03819-2.

Lin, Z., H. Akin, R. Rao, B. Hie, Z. Zhu, W. Lu, N. Smetanin, R. Verkuil, O. Kabeli, Y. Shmueli, A. dos Santos Costa, M. Fazel-Zarandi, T. Sercu, S. Candido, and A. Rives. 2023. “Evolutionary-scale prediction of atomic-level protein structure with a language model.” Science 379 (6637): 1123–1130. https://doi.org/10.1126/science.ade2574.

Mitchell, M., S. Wu, A. Zaldivar, P. Barnes, L. Vasserman, B. Hutchinson, E. Spitzer, I. D. Raji, and T. Gebru. 2019. “Model cards for model reporting.” Proceedings of the Conference on Fairness, Accountability, and Transparency. arXiv:1810.03993v2. https://doi.org/10.1145/3287560.3287596.

National Academies of Sciences, Engineering, and Medicine (NASEM). 2018. Biodefense in the Age of Synthetic Biology. Washington, DC: The National Academies Press. https://doi.org/10.17226/24890.

NASEM. 2025. The Age of AI in the Life Sciences: Benefits and Biosecurity Considerations. Washington, DC: The National Academies Press. https://doi.org/10.17226/28868.

National Research Council. 2004. Biotechnology Research in an Age of Terrorism. Washington, DC: The National Academies Press. https://doi.org/10.17226/10827.

OECD. 2025. Managing Emerging Critical Risks: Case Studies and Cross-Country Synthesis Report. Paris: OECD Publishing. https://doi.org/10.1787/1f9858ea-en.

Pannu, J., D. Bloomfield, R. MacKnight, M. S. Hanke, A. Zhu, G. Gomes, A. Cicero, and T. V. Inglesby. 2025. “Dual-use capabilities of concern of biological AI models.” PLOS Computational Biology 21 (5): e1012975. https://doi.org/10.1371/journal.pcbi.1012975.

Sever, R. 2023. “Biomedical publishing: Past historic, present continuous, future conditional.” PLOS Biology 21 (10): e3002234. https://doi.org/10.1371/journal.pbio.3002234.

“Statement on Scientific Publication and Security.” 2003. Science 299 (5610): 1149. https://doi.org/10.1126/science.299.5610.1149.

Urbina, F., F. Lentzos, C. Invernizzi, and S. Ekins. 2022. “Dual use of artificial-intelligence-powered drug discovery.” Nature Machine Intelligence 4 (3): 189–191. https://doi.org/10.1038/s42256-022-00465-9.

Urbina, F., F. Lentzos, C. Invernizzi, and S. Ekins. 2023. “AI in drug discovery: A wake-up call.” Drug Discovery Today 28 (1): 103410. https://doi.org/10.1016/j.drudis.2022.103410.

Watson, J. L., D. Juergens, N. R. Bennett, B. L. Trippe, J. Yim, H. E. Eisenach, W. Ahern, A. J. Borst, R. J. Ragotte, L. F. Milles, B. I. M. Wicky, N. Hanikel, S. J. Pellock, A. Courbet, W. Sheffler, J. Wang, P. Venkatesh, I. Sappington, S. V. Torres, A. Lauko, V. De Bortoli, E. Mathieu, S. Ovchinnikov, R. Barzilay, T. S. Jaakkola, F. DiMaio, M. Baek, and D. Baker. 2023. “De novo design of protein structure and function with RFdiffusion.” Nature 620 (7976): 1089–1100. https://doi.org/10.1038/s41586-023-06415-8.

Wein, L. M., and Y. Liu. 2005. “Analyzing a bioterror attack on the food supply: The case of botulinum toxin in milk.” Proceedings of the National Academy of Sciences 102 (28): 9984–9989. https://doi.org/10.1073/pnas.0408526102.

Wittmann, B. J., T. Alexanian, C. Bartling, J. Beal, A. Clore, J. Diggans, K. Flyangolts, B. T. Gemler, T. Mitchell, S. T. Murphy, N. E. Wheeler, and E. Horvitz. 2024. “Toward AI-resilient screening of nucleic acid synthesis orders: Process, results, and recommendations.” bioRxiv 2024.12.02.626439. https://doi.org/10.1101/2024.12.02.626439.

Suggested Citation: "References." National Academies of Sciences, Engineering, and Medicine. 2025. Disseminating In Silico and Computational Biological Research: Navigating Benefits and Risks: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/29174.
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Suggested Citation: "References." National Academies of Sciences, Engineering, and Medicine. 2025. Disseminating In Silico and Computational Biological Research: Navigating Benefits and Risks: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/29174.
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Next Chapter: Appendix A: Statement of Task
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