Drug Repurposing and Repositioning: Workshop Summary (2014)
Chapter: Appendix A: Workshop Agenda
Drug Repurposing and Repositioning
A Workshop
June 24, 2013
The Keck Center of the National Academies, Room 100
500 Fifth Street, NW
Washington, DC 20001
Workshop Objectives:
- To assess the current landscape of drug repurposing activities in industry, academia, and government.
- To examine enabling tools and technology for drug repurposing.
- To evaluate the business models and economic incentives for pursuing a repurposing approach.
- To discuss how genomic and genetic research could be positioned to better enable a drug repurposing paradigm.
| 8:30–8:35 A.M. | Welcoming Remarks |
|
Sharon F. Terry, Roundtable Co-Chair |
|
|
President and Chief Executive Officer Genetic Alliance |
|
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Geoffrey Ginsburg, Roundtable Co-Chair |
|
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Director, Genomic Medicine, Duke Institute for Genome Sciences & Policy; Executive Director, Center for Personalized Medicine, Duke Medicine; Professor of Medicine and Pathology, Duke University Medical Center |
|
| 8:35–8:40 A.M. |
Charge to Workshop Speakers and Participants |
|
Aidan Power, Workshop Chair |
|
|
Vice President and Head, PharmaTx Precision Medicine |
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Pfizer Inc. |
|
| 8:40–10:20 A.M. | SESSION I: CURRENT LANDSCAPE Moderator: Gabriela Lavezzari Assistant Vice President, Scientific Affairs PhRMA |
|
8:40–8:55 A.M. |
State of the Science: Academia |
|
Larry Sklar |
|
|
Distinguished Professor |
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Director, Center for Molecular Discovery |
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Associate Director, Cancer Center |
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University of New Mexico School of Medicine |
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8:55–9:10 A.M. |
State of the Science: Industry |
|
Don Frail |
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Vice President of Science |
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New Opportunities Innovative Medicines Unit |
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AstraZeneca |
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9:10–9:25 A.M. |
State of the Science: FDA |
|
Weida Tong |
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Director, Division of Bioinformatics and Biostatistics |
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National Center for Toxicological Research |
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U.S. Food and Drug Administration |
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9:25–9:40 A.M. |
State of the Science: Rare Disease |
|
Hal Dietz |
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Victor A. McKusick Professor of Medicine and Genetics |
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Institute of Genetic Medicine |
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Investigator, Howard Hughes Medical Institute |
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Johns Hopkins University School of Medicine |
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|
9:40–10:20 A.M. |
Discussion with Speakers and Attendees |
| 10:20–10:35 A.M. |
BREAK |
| 10:35 A.M. –12:30 P.M. |
SESSION II: ENABLING TOOLS AND TECHNOLOGY |
|
Moderator: Geoffrey Ginsburg |
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Director, Genomic Medicine, Duke Institute for Genome Sciences & Policy; Executive Director, Center for Personalized Medicine, Duke Medicine; Professor of Medicine and Pathology, Duke University Medical Center |
|
|
10:35–10:55 A.M. |
Computational Strategies (modeling, literature-based discovery) |
|
Atul Butte |
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Chief and Associate Professor of Systems Medicine |
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Department of Pediatrics |
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Stanford University School of Medicine |
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10:55–11:15 A.M. |
Data Mining (post-market surveillance, high-throughput screening, databases) |
|
Lon Cardon |
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Senior Vice President, Alternative Discovery and Development |
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GlaxoSmithKline |
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|
11:15–11:30 A.M. |
Government-Sponsored Efforts: NCATS |
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John McKew |
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Acting Director, Division of Pre-Clinical Innovation |
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National Center for Advancing Translational Sciences |
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11:30–11:45 A.M. |
Government-Sponsored Efforts: NINDS |
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Petra Kaufmann |
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Director, Office of Clinical Research |
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National Institute of Neurological Disorders and Stroke |
|
|
11:45 A.M. –12:30 P.M. |
Discussion with Speakers and Attendees |
| 12:30–1:20 P.M. |
WORKING LUNCH |
| 1:20–2:45 P.M. |
SESSION III: VALUE PROPOSITION FOR REPURPOSING |
|
Moderator: Allen Roses |
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Jefferson–Pilot Professor of Neurobiology and Genetics |
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Professor of Medicine (Neurology) |
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Director, Deane Drug Discovery Institute |
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Senior Scholar Fuqua School of Business, R. David Thomas Executive Training Center Duke University |
|
|
1:20–1:35 P.M. |
Business Model/Economic Incentives |
|
Michael Ringel |
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Partner and Managing Director |
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The Boston Consulting Group |
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|
1:35–1:50 P.M. |
Repurposing Drugs Currently in Development |
|
Simeon Taylor |
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|
Vice President, Research and Scientific Affairs |
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Bristol-Myers Squibb |
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|
1:50–2:05 P.M. |
Repurposing Drugs That Were Not Successful for Their First Indication |
|
Thomas O. Daniel |
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|
Executive Vice President |
|
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President, Global Research and Early Development |
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Celgene Corporation |
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|
2:05–2:45 P.M. |
Discussion with Speakers and Attendees |
| 2:45–3:00 P.M. |
BREAK |
| 3:00–4:25 P.M. |
SESSION IV: POLICY APPROACHES AND LEGAL FRAMEWORK |
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Moderator: Arti Rai |
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Elvin R. Latty Professor of Law |
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Duke University |
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|
3:00–3:15 P.M. |
Strategies for Overcoming Barriers to Drug Repurposing: NCATS |
|
Christine Colvis |
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Director, Extramural Therapeutics Discovery |
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National Center for Advancing Translational Sciences |
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3:15–3:30 P.M. |
Strategies for Overcoming Barriers to Drug Repurposing: MRC/AZ |
|
Chris Watkins |
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|
Director, Translational Research and Industry Medical Research Council |
|
|
3:30–3:45 P.M. |
Legal/Intellectual Property |
|
Arti Rai |
|
|
Elvin R. Latty Professor of Law |
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|
Duke University |
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|
3:45–4:25 P.M. |
Discussion with Speakers and Attendees |
| 4:25–5:15 P.M. |
SESSION V: INCREASING THE EFFICIENCY AND SUCCESS OF REPURPOSING |
|
4:25–5:15 P.M. |
Advancing Repurposing Efforts |
|
Moderator: Aidan Power, Workshop Chair |
|
|
Vice President and Head, PharmaTx Precision Medicine |
|
|
Pfizer Inc. |
|
|
Respondents: |
|
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Ronald J. Bartek |
|
|
President |
|
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Friedreich’s Ataxia Research Alliance |
|
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Lon Cardon |
|
|
Senior Vice President, Alternative Discovery and Development |
|
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GlaxoSmithKline |
|
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Christine Colvis |
|
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Director, Extramural Therapeutics Discovery |
|
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National Center for Advancing Translational Sciences |
|
|
Hal Dietz |
|
|
Victor A. McKusick Professor of Medicine and Genetics |
|
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Institute of Genetic Medicine |
|
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Investigator, Howard Hughes Medical Institute Johns Hopkins University School of Medicine |
|
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Michael Pacanowski |
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Acting Associate Director for Genomics |
|
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Center for Drug Evaluation and Research |
|
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Office of Clinical Pharmacology |
|
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U.S. Food and Drug Administration |
|
|
Arti Rai |
|
|
Elvin R Latty Professor of Law |
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Duke University |
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Michael Ringel |
|
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Partner and Managing Director |
|
|
The Boston Consulting Group |
|
| 5:15–5:30 P.M. |
SESSION VI: CONCLUSION |
| 5:15–5:30 P.M. |
CONCLUDING REMARKS |
|
Aidan Power, Workshop Chair |
|
|
Vice President and Head, PharmaTx Precision Medicine |
|
|
Pfizer Inc. |
|
| 5:30 P.M. |
ADJOURN |
