Human Genome Editing Initiative

Summit

Third International Summit on Human Genome Editing

March 6 - 8, 2023

Past

Materials

Summit Brochure

About

This was the Third International Summit on Human Genome Editing. It was organized as a collaborative activity of the the U.K.’s Royal Society and Academy of Medical Sciences, the U.S. National Academy of Sciences and U.S. National Academy of Medicine, and The World Academy of Sciences and brought together leading experts to examine the potential risks and benefits of genome editing technologies and the significant ethical and societal issues associated with advances in human genome editing research.

Organizing Project

Third International Summit on Human Genome Editing

Contact

Steven Kendall

(202) 334-1713
skendall@nas.edu

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

Webinar

Heritable Human Genome Editing: Rare Disease Week Discussion - Virtual Event

February 26, 2021

9:00 AM - 10:30 AM (EST)

Past

Agenda

Download the Agenda

About

Heritable human genome editing has been proposed as a means of helping parents with a known risk of passing on a genetic disease to avoid that risk. But can the technology be used safely and if so, in what circumstances should it be considered for any initial use?

On February 26, 2021, members of the International Commission on the Clinical Use of Human Germline Genome Editing participated in an online discussion of the implications of this technology for genetic disease and disability communities.

At the webinar, Commission members discussed with participants recommendations from its 2020 report around the following questions:

What are existing and potential options for parents at risk of passing on a genetic disease?
Is heritable human genome editing safe and effective enough to be used clinically?
What criteria may be required for initial human uses of heritable editing, should a society permit them?
How should any future use of heritable human genome editing be governed?

The session was moderated by Sharon Terry, Genetic Alliance. She was be joined by Commission members Kay Davies, University of Oxford, Richard Lifton, Rockefeller University, Andy Greenfield, MRC Harwell Institute, Jeffrey Kahn, Johns Hopkins University, and Anna Wedell, Karolinska Institute.

View video of the event athttps://vimeo.com/showcase/8231735.

Additional Information

Is it a Closed Session event?

Not Closed

Organizing Project

International Commission on the Clinical Use of Human Germline Genome Editing

Contact

Dominic LoBuglio

GeneEditing@nas.edu

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

Webinar

International Commission on the Clinical Use of Human Germline Genome Editing - Report Release Webinar

September 3, 2020

10:15 AM - 11:15 AM (EDT)

Past

About

This webinar presented the findings and recommendations of the International Commission on the Clinical Use of Human Germline Genome Editing.

View video of the event here: https://vimeo.com/showcase/7518014

Additional Information

Is it a Closed Session event?

Not Closed

Organizing Project

International Commission on the Clinical Use of Human Germline Genome Editing

Contact

Dominic LoBuglio

GeneEditing@nas.edu

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

Tele Conference Closed

International Commission on the Clinical Use of Human Germline Genome Editing - Teleconference 18

August 7, 2020

9:00 AM - 11:00 AM (EDT)

Past

About

This will be a conference call of the international commission developing a framework for considering technical, scientific, medical, regulatory, and ethical requirements for germline genome editing (should society conclude such applications are acceptable). It will be closed in its entirety.

Additional Information

Is it a Closed Session event?

Institution Closed

The following committee members were present at the closed sessions of the event

Kay Davies
Richard Lifton
Michele Ramsay
Andy Greenfield
Dana Carroll
Jeff Kahn
Bartha Knoppers
BK Thelma
Rahman Jamal
Susan Golombok
Hide Akutsu
Doug Turnbull
Haoyi Wang

The following topics were discussed in the closed sessions:

The Commission discussed its draft report

The following materials (written documents) were made available to the committee in the closed sessions:

None

Date of posting of Closed Session Summary:

August 07, 2020

Organizing Project

International Commission on the Clinical Use of Human Germline Genome Editing

Contact

Dominic LoBuglio

dlobuglio@nas.edu

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

Tele Conference Closed

International Commission on the Clinical Use of Human Germline Genome Editing - Teleconference 17

August 6, 2020

8:30 AM - 9:30 AM (EDT)

Past

About

This will be a conference call of the international commission developing a framework for considering technical, scientific, medical, regulatory, and ethical requirements for germline genome editing (should society conclude such applications are acceptable). It will be closed in its entirety.

Additional Information

Is it a Closed Session event?

Institution Closed

The following committee members were present at the closed sessions of the event

Kay Davies
Richard Lifton
Dana Carroll
BK Thelma
Andy Greenfield
Doug Turnbull
Hide Akutsu
Jeffrey Kahn
Susan Golombok
Anna Wedell
Rahman Jamal
Haoyi Wang
Rob Califf
Bartha Knoppers
Michele Ramsay

The following topics were discussed in the closed sessions:

The Commission discussed its draft report

The following materials (written documents) were made available to the committee in the closed sessions:

None

Date of posting of Closed Session Summary:

August 06, 2020

Organizing Project

International Commission on the Clinical Use of Human Germline Genome Editing

Contact

Dominic LoBuglio

dlobuglio@nas.edu

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

Closed

International Commission on the Clinical Use of Human Germline Genome Editing - Teleconference 16

July 31, 2020

9:00 AM - 11:00 AM (EDT)

Past

About

This will be a conference call of the international commission developing a framework for considering technical, scientific, medical, regulatory, and ethical requirements for germline genome editing (should society conclude such applications are acceptable). It will be closed in its entirety.

Additional Information

Is it a Closed Session event?

Institution Closed

The following committee members were present at the closed sessions of the event

Kay Davies
Richard Lifton
Jeff Kahn
Anna Wedell
Andy Greenfield
Rob Califf
Dana Carroll
Eric Lander
Susan Golombok
Hide Akutsu
Bartha Knoppers
Doug Turnbull
Michele Ramsay
BK Thelma
Jinsong Li
Haoyi Wang
Julie Steffann

The following topics were discussed in the closed sessions:

The Commission discussed its draft report.

The following materials (written documents) were made available to the committee in the closed sessions:

None.

Date of posting of Closed Session Summary:

July 31, 2020

Organizing Project

International Commission on the Clinical Use of Human Germline Genome Editing

Contact

Dominic LoBuglio

dlobuglio@nas.edu

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

Tele Conference Closed

International Commission on the Clinical Use of Human Germline Genome Editing - Teleconference 15

July 24, 2020

9:00 AM - 11:00 AM (EDT)

Past

About

This will be a conference call of the international commission developing a framework for considering technical, scientific, medical, regulatory, and ethical requirements for germline genome editing (should society conclude such applications are acceptable). It will be closed in its entirety.

Additional Information

Is it a Closed Session event?

Institution Closed

The following committee members were present at the closed sessions of the event

Richard Lifton
Julie Steffann
Susan Golombok
Hide Akutsu
Haoyi Wang
Anna Wedell
BK Thelma
Dana Carroll
Doug Turnbull
Jeff Kahn
Michele Ramsay
Rahman Jamal
Bartha Knoppers
Eric Lander
Rob Califf

The following topics were discussed in the closed sessions:

The Commission discussed its draft report.

The following materials (written documents) were made available to the committee in the closed sessions:

None.

Date of posting of Closed Session Summary:

July 31, 2020

Organizing Project

International Commission on the Clinical Use of Human Germline Genome Editing

Contact

Dominic LoBuglio

dlobuglio@nas.edu

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

Tele Conference Closed

International Commission on the Clinical Use of Human Germline Genome Editing - Teleconference 14

July 10, 2020

9:00 AM - 11:00 AM (EDT)

Past

About

This will be a conference call of the international commission developing a framework for considering technical, scientific, medical, regulatory, and ethical requirements for germline genome editing (should society conclude such applications are acceptable). It will be closed in its entirety.

Additional Information

Is it a Closed Session event?

Institution Closed

The following committee members were present at the closed sessions of the event

Kay Davies
Richard Lifton
Andy Greenfield
Dana Carroll
Anna Wedell
Bartha Knoppers
Doug Turnbull
Rob Califf
Julie Steffann
Michele Ramsay
BK Thelma
Eric Lander
Jeff Kahn
Susan Golombok
Hide Akutsu
Haoyi Wang

The following topics were discussed in the closed sessions:

The Commission discussed its draft report.

The following materials (written documents) were made available to the committee in the closed sessions:

None.

Date of posting of Closed Session Summary:

July 10, 2020

Organizing Project

International Commission on the Clinical Use of Human Germline Genome Editing

Contact

Dominic LoBuglio

dlobuglio@nas.edu

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

Closed

International Commission on the Clinical Use of Human Germline Genome Editing - Teleconference 13

June 26, 2020

9:00 AM - 11:00 AM (EDT)

Past

About

This will be a conference call of the international commission developing a framework for considering technical, scientific, medical, regulatory, and ethical requirements for germline genome editing (should society conclude such applications are acceptable). It will be closed in its entirety.

Additional Information

Is it a Closed Session event?

Institution Closed

The following committee members were present at the closed sessions of the event

Kay Davies
Richard Lifton
Andy Greenfield
Dana Carroll
Hide Akutsu
Doug Turnbull
Michele Ramsay
Anna Wedell
BK Thelma
Haoyi Wang
Julie Steffann
Jeff Kahn
Susan Golombok
Jinsong Li
Bartha Knoppers
Rahman Jamal
Eric Lander
Rob Califf

The following topics were discussed in the closed sessions:

The Commission discussed its draft report

The following materials (written documents) were made available to the committee in the closed sessions:

None.

Date of posting of Closed Session Summary:

June 26, 2020

Organizing Project

International Commission on the Clinical Use of Human Germline Genome Editing

Contact

Dominic LoBuglio

dlobuglio@nas.edu

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

Tele Conference Closed

International Commission on the Clinical Use of Human Germline Genome Editing - Teleconference 12

June 19, 2020

9:00 AM - 11:00 AM (EDT)

Past

About

This will be a conference call of the international commission developing a framework for considering technical, scientific, medical, regulatory, and ethical requirements for germline genome editing (should society conclude such applications are acceptable). It will be closed in its entirety.

Additional Information

Is it a Closed Session event?

Institution Closed

The following committee members were present at the closed sessions of the event

Kay Davies
Richard Lifton
Andy Greenfield
Bartha Knoppers
Rob Califf
Dana Carroll
Doug Turnbull
Eric Lander
Jeff Kahn
Jinsong Li
Julie Steffann
Michele Ramsay
BK Thelma
Rahman Jamal
Haoyi Wang
Susan Golombok

The following topics were discussed in the closed sessions:

The commission discussed its draft report.

The following materials (written documents) were made available to the committee in the closed sessions:

None.

Date of posting of Closed Session Summary:

June 19, 2020

Organizing Project

International Commission on the Clinical Use of Human Germline Genome Editing

Contact

Dominic LoBuglio

dlobuglio@nas.edu

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

Tele Conference Closed

International Commission on the Clinical Use of Human Germline Genome Editing - Teleconference 11

June 12, 2020

9:00 AM - 11:00 AM (EDT)

Past

About

This will be a conference call of the international commission developing a framework for considering technical, scientific, medical, regulatory, and ethical requirements for germline genome editing (should society conclude such applications are acceptable). It will be closed in its entirety.

Additional Information

Is it a Closed Session event?

Institution Closed

The following committee members were present at the closed sessions of the event

Kay Davies
Richard Lifton
Bartha Knoppers
Dana Carroll
Jinsong Li
Andy Greenfield
Hide Akutsu
Doug Turnbull
Haoyi Wang
Julie Steffann
Anna Wedell
Michele Ramsay
Jeff Kahn
BK Thelma
Eric Lander
Susan Golombok

The following topics were discussed in the closed sessions:

The Commission discussed its draft report.

The following materials (written documents) were made available to the committee in the closed sessions:

None.

Organizing Project

International Commission on the Clinical Use of Human Germline Genome Editing

Contact

Dominic LoBuglio

dlobuglio@nas.edu

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

Tele Conference Closed

International Commission on the Clinical Use of Human Germline Genome Editing - Teleconference 10

June 5, 2020

9:36 AM - 10:00 AM (EDT)

Past

About

This will be a conference call of the international commission developing a framework for considering technical, scientific, medical, regulatory, and ethical requirements for germline genome editing (should society conclude such applications are acceptable). It will be closed in its entirety.

Additional Information

Is it a Closed Session event?

Institution Closed

The following committee members were present at the closed sessions of the event

Kay Davies
Richard Lifton
Bartha Knoppers
Dana Carroll
Hide Akutsu
Andy Greenfield
Jeffrey Kahn
Anna Wedell
Susan Golombok
Doug Turnbull
Rahman Jamal
Julie Steffann
Haoyi Wang
BK Thelma
Eric Lander

The following topics were discussed in the closed sessions:

The Commission discussed its draft report.

The following materials (written documents) were made available to the committee in the closed sessions:

None.

Date of posting of Closed Session Summary:

June 08, 2020

Organizing Project

International Commission on the Clinical Use of Human Germline Genome Editing

Contact

Dominic LoBuglio

dlobuglio@nas.edu

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

Tele Conference Closed

International Commission on the Clinical Use of Human Germline Genome Editing - Teleconference 9

April 24, 2020

10:00 AM - 12:00 PM (EDT)

Past

About

This will be a conference call of the international commission developing a framework for considering technical, scientific, medical, regulatory, and ethical requirements for germline genome editing (should society conclude such applications are acceptable). It will be closed in its entirety.

Additional Information

Is it a Closed Session event?

Institution Closed

The following committee members were present at the closed sessions of the event

Kay Davies
Richard Lifton
Andy Greenfield
Anna Wedell
Dana Carroll
Susan Golombok
Hide Akutsu
Rahman Jamal
B.K. Thelma
Doug Turnbull
Bartha Knoppers
Eric Lander
Rob Califf
Haoyi Wang
Michele Ramsay
Julie Steffann

The following topics were discussed in the closed sessions:

The Commissioners discussed their draft report

The following materials (written documents) were made available to the committee in the closed sessions:

none.

Date of posting of Closed Session Summary:

April 24, 2020

Organizing Project

International Commission on the Clinical Use of Human Germline Genome Editing

Contact

Dominic LoBuglio

dlobuglio@nas.edu

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

Tele Conference Closed

International Commission on the Clinical Use of Human Germline Genome Editing - Teleconference 8

April 17, 2020

10:00 AM - 12:00 PM (EDT)

Past

About

This will be a conference call of the international commission developing a framework for considering technical, scientific, medical, regulatory, and ethical requirements for germline genome editing (should society conclude such applications are acceptable). It will be closed in its entirety.

Additional Information

Is it a Closed Session event?

Institution Closed

The following committee members were present at the closed sessions of the event

Kay Davies
Bartha Knoppers
Eric Lander
Dana Carroll
Andy Greenfield
Anna Wedell
Hide Akutsu
Julie Steffann
Jeff Kahn
Rahman Jamal
Haoyi Wang
Rob Califf
Doug Turnbull
Susan Golombok
Michele Ramsay
B.K. Thelma

The following topics were discussed in the closed sessions:

The Commissioners discussed their draft report.

The following materials (written documents) were made available to the committee in the closed sessions:

none.

Date of posting of Closed Session Summary:

April 24, 2020

Organizing Project

International Commission on the Clinical Use of Human Germline Genome Editing

Contact

Dominic LoBuglio

dlobuglio@nas.edu

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

Tele Conference Closed

International Commission on the Clinical Use of Human Germline Genome Editing - Commission Teleconference 7

March 20, 2020

10:00 AM - 11:00 AM (EDT)

Past

About

This will be a conference call of the international commission developing a framework for considering technical, scientific, medical, regulatory, and ethical requirements for germline genome editing (should society conclude such applications are acceptable). It will be closed in its entirety.

Additional Information

Is it a Closed Session event?

Institution Closed

The following committee members were present at the closed sessions of the event

Kay Davies, Richard Lifton, Hide Akutsu, Dana Carroll, Susan Golombok, Andy Greenfield, Jeffrey Kahn, Bartha Knoppers, Eric Lander, Michele Ramsay, Julie Steffann, BK Thelma, Doug Turnbull, Haoyi Wang, Anna Wedell.

The following topics were discussed in the closed sessions:

The Commission discussed its draft report.

The following materials (written documents) were made available to the committee in the closed sessions:

none.

Date of posting of Closed Session Summary:

March 23, 2020

Organizing Project

International Commission on the Clinical Use of Human Germline Genome Editing

Contact

Dominic LoBuglio

dlobuglio@nas.edu

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

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Human Genome Editing Initiative

News and Updates

Third International Summit on Human Genome Editing

Heritable Human Genome Editing: Rare Disease Week Discussion - Virtual Event

International Commission on the Clinical Use of Human Germline Genome Editing - Report Release Webinar

International Commission on the Clinical Use of Human Germline Genome Editing - Teleconference 18

International Commission on the Clinical Use of Human Germline Genome Editing - Teleconference 17

International Commission on the Clinical Use of Human Germline Genome Editing - Teleconference 16

International Commission on the Clinical Use of Human Germline Genome Editing - Teleconference 15

International Commission on the Clinical Use of Human Germline Genome Editing - Teleconference 14

International Commission on the Clinical Use of Human Germline Genome Editing - Teleconference 13

International Commission on the Clinical Use of Human Germline Genome Editing - Teleconference 12

International Commission on the Clinical Use of Human Germline Genome Editing - Teleconference 11

International Commission on the Clinical Use of Human Germline Genome Editing - Teleconference 10

International Commission on the Clinical Use of Human Germline Genome Editing - Teleconference 9

International Commission on the Clinical Use of Human Germline Genome Editing - Teleconference 8

International Commission on the Clinical Use of Human Germline Genome Editing - Commission Teleconference 7