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Suggested Citation: "Appendix A: Symposium Agenda." National Academies of Sciences, Engineering, and Medicine. 2025. Gilbert W. Beebe Symposium: AI and ML Applications in Radiation Therapy, Medical Diagnostics, and Radiation Occupational Health and Safety. Washington, DC: The National Academies Press. doi: 10.17226/29200.

Appendix A
Symposium Agenda

PROGRAM

The symposium will include a community discussion on algorithm development and pathways to success, a focus on future directions and opportunities in AI/ML methods and technology to advance the fields of the radiation health sciences, and discussions on the intentionality of data collection for algorithm development and training, as well as focused breakout sessions on current and emerging applications of AI and ML in the radiation health science fields. Sessions will consider such topics as Broader AI Community Discussions, Future Directions and Opportunities for AI/ML Applications in the Radiation Health Sciences, Data for AI Readiness, AI in the Clinic—Applications in Radiation Oncology and Medical Diagnostics, AI Applications in Occupational and Public Health, and AI Regulations and Ethics.

DAY 1 | THURSDAY, MARCH 13, 2025 (All times are U.S. Eastern)

8:00 AM Call to Order and Welcome
Charles D. Ferguson, National Academies of Sciences, Engineering, and Medicine
Session One | Broader AI Community Discussions

This session aims to engage thought leaders in the broader AI community to share insights from AI developers, users, and government regulators on balancing the benefits of rapid AI innovation and the risks. Talks will address key responsible AI principles in AI model development, human decision making in AI, ethical considerations, and acceptable uncertainty levels for model outputs.

Session Introduction and Overview
Co-moderated by Leo Chiang, Co-Chair, The Dow Chemical Company
Co-moderated by Shaheen Dewji, Co-Chair, Georgia Institute of Technology
8:05 AM Transformational AI Opportunities in Healthcare
David C. Rhew, Microsoft
Suggested Citation: "Appendix A: Symposium Agenda." National Academies of Sciences, Engineering, and Medicine. 2025. Gilbert W. Beebe Symposium: AI and ML Applications in Radiation Therapy, Medical Diagnostics, and Radiation Occupational Health and Safety. Washington, DC: The National Academies Press. doi: 10.17226/29200.
8:35 AM The Journey to Safe and Effective AI Adoption
Mike Tilkin, American College of Radiology
9:05 AM Session One | Panel Discussion
9:45 AM BREAK (10 minutes)

Session Two | Future Directions and Opportunities

This session will explore AI’s primary focus areas within each subfield, covering current practices, emerging developments, and challenges to advancing applications. Presenters will discuss both model development and strategic pathways for implementing AI across radiation therapy, diagnostics, occupational health, and environmental safety. The session will emphasize human oversight, ethical considerations, and responsible AI integration to support effective, reliable decision making in these diverse fields.

Session Two A | Future Directions and Opportunities

9:55 AM Session Introduction and Overview | Radiation Therapy/Oncology
Co-moderated by Anyi Li, Planning Committee, Memorial Sloan Kettering Cancer Center
Co-moderated by Ceferino Obcemea, Planning Committee, National Cancer Institute
10:00 AM AI Agents for Adaptive Radiotherapy
Steve Jiang, University of Texas Southwestern
10:15 AM Multi-omics Integration and Pattern Discovery in Patient Data Using Spatially
Semantic Topographic Maps
Lei Xing, Stanford University
10:30 AM Session Two A | Panel Discussion
Session Two B | Future Directions and Opportunities
11:10 AM Session Introduction and Overview | Medical Diagnostics
Moderated by Caroline Chung, Planning Committee, MD Anderson Cancer Center
11:15 AM Quantitative MR, Promising Data as a Replacement of CT
Cameron Piron, Synaptive Medical
11:30 AM AI and Quantitative Imaging
Jayashree Kalpathy-Cramer, University of Colorado-Anschutz Medical Campus
11:45 AM Session Two B | Panel Discussion
12:25 PM LUNCH (1 hour)
Suggested Citation: "Appendix A: Symposium Agenda." National Academies of Sciences, Engineering, and Medicine. 2025. Gilbert W. Beebe Symposium: AI and ML Applications in Radiation Therapy, Medical Diagnostics, and Radiation Occupational Health and Safety. Washington, DC: The National Academies Press. doi: 10.17226/29200.

Session Two C | Future Directions and Opportunities

1:25 PM Session Introduction and Overview | AI/ML Innovations in Radiation Occupational Health
Moderated by Sylvain Costes, Planning Committee, NASA
1:30 PM Computational Approaches to Assessing Radiation Exposure Across the Life Course: Risks, Insights, and Innovations
Heidi Hanson, Oak Ridge National Laboratory
1:45 PM Patient-Centric Synthetic Data Generation, No Reason to Risk Re-identification in Biomedical Data Analysis: The Anonymous Synthetic Data Era
Pierre-Antoine Gourraud, Nantes Université, University Medical Center (CHU de Nantes), France
2:00 PM Session Two C | Panel Discussion
2:40 PM BREAK (10 minutes)

Session Three | Data for AI Readiness

This session will explore the significance of intentional data collection for trustworthy AI model results with a focus on medical imaging as an example. Key topics include data quality and quantity requirements, data collection planning, and data management strategies. Discussion will focus on tackling major gaps, bias, and ethical considerations in radiation health sciences data while suggesting innovative solutions.

2:50 PM Session Introduction and Overview
Co-moderated by Leo Chiang, Co-Chair, The Dow Chemical Company
Co-moderated by Anyi Li, Planning Committee, Memorial Sloan Kettering Cancer Center
2:55 PM Data for AI: The Critical Role of Metadata and Context
Caroline Chung, MD Anderson Cancer Center
3:10 PM Requisites and Challenges in Quantitative Imaging
Daniel C. Sullivan, Duke University Medical Center
3:25 PM Centralized Imaging Collaborations for AI Readiness
Paul Kinahan, University of Washington
3:40 PM Data Management Tools and Strategy for Responsible Imaging AI
Daniel Marcus, Washington University School of Medicine in St. Louis
3:55 PM Session Three | Panel Discussion
4:05 PM BREAK (10 minutes)
Suggested Citation: "Appendix A: Symposium Agenda." National Academies of Sciences, Engineering, and Medicine. 2025. Gilbert W. Beebe Symposium: AI and ML Applications in Radiation Therapy, Medical Diagnostics, and Radiation Occupational Health and Safety. Washington, DC: The National Academies Press. doi: 10.17226/29200.

Session Four | Community Discussion and End-of-Day Notes

4:15 PM Radiation Therapy Wrap-up
Report from Anyi Li
4:25 PM Medical Diagnostics Wrap-up
Report from Caroline Chung
4:35 PM Exposure Assessment Wrap-up
Report from Sylvain Costes
4:45 PM End of Day, Closing Remarks, and Summary on Common Themes
Shaheen Dewji
5:00 PM Adjourn | End of Day 1 of Symposium

Day 2 will provide a platform for invited speakers and participants to present and discuss advancements in AI and ML across diverse areas of radiation science, including health, occupational safety, environmental monitoring, and regulatory frameworks. Moderated panel sessions will build on insights from Day 1’s “Future Directions and Opportunities” session, advancing discussions on the application, ethical considerations, and governance of AI across multiple radiation-related fields. This day’s agenda will support a comprehensive exploration of AI’s role in enhancing radiation safety, data integration, and regulatory processes, fostering collaboration among experts from varied domains within radiation science.

DAY 2 | FRIDAY, MARCH 14, 2025 (All times are U.S. Eastern.)

8:00 AM Welcome and Overview for Day 2
Leo Chiang, Co-Chair, The Dow Chemical Company
Shaheen Dewji, Co-Chair, Georgia Institute of Technology
Session Five | Breakout Sessions Five A and Five B

Breakout Session Five A | Location—Fred Kavli Auditorium

8:05 AM Session Five A | Digital Twins
Session Introduction and Overview
Co-moderated by Caroline Chung, Planning Committee, MD Anderson Cancer Center
Co-moderated by Sylvain Costes, Planning Committee, NASA
8:15 AM Cardiac Digital Twins: From the Academy to the Clinic
Charles A. Taylor, University of Texas at Austin
8:40 AM Digital Twins for Disease Modeling and Drug Development
Jon Walsh, Unlearn
Suggested Citation: "Appendix A: Symposium Agenda." National Academies of Sciences, Engineering, and Medicine. 2025. Gilbert W. Beebe Symposium: AI and ML Applications in Radiation Therapy, Medical Diagnostics, and Radiation Occupational Health and Safety. Washington, DC: The National Academies Press. doi: 10.17226/29200.
9:05 AM Multiscale Digital Twins for Personalized Radiopharmaceutical Therapy
Greeshma Agasthya, Georgia Institute of Technology
9:30 AM DT and AI for Precision Medicine
Jun Deng, Yale University
9:55 AM Session Five A | Panel Discussion
11:00 AM LUNCH (1 hour)

Breakout Session Five B | Location—NAS 120

8:05 AM Session Five B | AI/ML Applications of Multimodal Modeling
Session Introduction and Overview
Co-moderated by Anyi Li, Planning Committee, Memorial Sloan Kettering Cancer Center
Co-moderated by Ceferino Obcemea, Planning Committee, National Cancer Institute
8:15 AM Integrating Mechanistic Modeling with Machine Learning to Evaluate Radiotherapy and Chemotherapy Outcomes in Head and Neck Cancer
Igor Shuryak, Columbia University Irving Medical Center (CUIMC)
8:40 AM Rapidly Exploring Use Cases for Multimodal AI in Radiology
Nur Yildirim, University of Virginia
9:05 AM Understanding Radiation Risk Through Deep Learning: Promise and Challenges
Zhenqiu Liu, Radiation Effects Research Foundation (RERF), Japan
9:30 AM AI and Multimodal Modeling in Lung Cancer
Jia Wu, MD Anderson Cancer Center
9:55 AM Session Five B | Panel Discussion
11:00 AM LUNCH (1 hour)

Session Six | Breakout Sessions Six A and Six B
Breakout Session Six A | Location—Fred Kavli Auditorium

12:00 PM Session Six A | Ethics and Bias
Session Introduction and Overview
Moderated by Leo Chiang, Co-Chair, The Dow Chemical Company
12:00 PM Artificial Intelligence Preparedness—A Regulatory Perspective
Matt Dennis, U.S. Nuclear Regulatory Commission
Suggested Citation: "Appendix A: Symposium Agenda." National Academies of Sciences, Engineering, and Medicine. 2025. Gilbert W. Beebe Symposium: AI and ML Applications in Radiation Therapy, Medical Diagnostics, and Radiation Occupational Health and Safety. Washington, DC: The National Academies Press. doi: 10.17226/29200.
12:25 PM Issues in the Use of AI for Breast Cancer Screening
Etta D. Pisano, American College of Radiology
12:50 PM Addressing Bias in AI-Driven Medical Imaging: Pitfalls and Best Practices
Amber Simpson, Queen’s University, Canada
1:15 PM Shortcuts Causing Bias in Medical Imaging
Judy Wawira Gichoya, Emory University School of Medicine
1:40 PM Session Six A | Panel Discussion
2:40 PM BREAK (20 minutes)

Breakout Session Six B | Location—NAS 120

12:00 PM Session Six B | Uncertainty Quantification and Trustworthiness
Session Introduction and Overview
Co-moderated by Shaheen Dewji, Co-Chair, Georgia Institute of Technology
Co-moderated by Ceferino Obcemea, Planning Committee, National Cancer Institute
12:00 PM Assessing Uncertainty in Indoor Radon Exposure Estimates: Implications for Radiation Epidemiology
Heidi Hanson, Oak Ridge National Laboratory
12:25 PM Enhancing Trustworthiness: A Case Study on Blood Pressure Modeling with Physics-Informed Neural Networks
Roozbeh Jafari, Massachusetts Institute of Technology Lincoln Laboratory
12:50 PM Jie Yu, Johnson & Johnson
1:15 PM Machine Learning and Low-Field MRI: Unlocking a New Class of Portable Scanners
Matthew Rosen, Harvard Medical School
1:40 PM Session Six B | Panel Discussion
2:40 PM BREAK (20 minutes)
3:00 PM Summary of Symposium and Highlight Discussions
Leo Chiang, Co-Chair
Shaheen Dewji, Co-Chair
Daniel Mulrow, National Academies Symposium Director
3:15 PM Adjourn Symposium | End of Day 2 Symposium
Suggested Citation: "Appendix A: Symposium Agenda." National Academies of Sciences, Engineering, and Medicine. 2025. Gilbert W. Beebe Symposium: AI and ML Applications in Radiation Therapy, Medical Diagnostics, and Radiation Occupational Health and Safety. Washington, DC: The National Academies Press. doi: 10.17226/29200.
Page 84
Suggested Citation: "Appendix A: Symposium Agenda." National Academies of Sciences, Engineering, and Medicine. 2025. Gilbert W. Beebe Symposium: AI and ML Applications in Radiation Therapy, Medical Diagnostics, and Radiation Occupational Health and Safety. Washington, DC: The National Academies Press. doi: 10.17226/29200.
Page 85
Suggested Citation: "Appendix A: Symposium Agenda." National Academies of Sciences, Engineering, and Medicine. 2025. Gilbert W. Beebe Symposium: AI and ML Applications in Radiation Therapy, Medical Diagnostics, and Radiation Occupational Health and Safety. Washington, DC: The National Academies Press. doi: 10.17226/29200.
Page 86
Suggested Citation: "Appendix A: Symposium Agenda." National Academies of Sciences, Engineering, and Medicine. 2025. Gilbert W. Beebe Symposium: AI and ML Applications in Radiation Therapy, Medical Diagnostics, and Radiation Occupational Health and Safety. Washington, DC: The National Academies Press. doi: 10.17226/29200.
Page 87
Suggested Citation: "Appendix A: Symposium Agenda." National Academies of Sciences, Engineering, and Medicine. 2025. Gilbert W. Beebe Symposium: AI and ML Applications in Radiation Therapy, Medical Diagnostics, and Radiation Occupational Health and Safety. Washington, DC: The National Academies Press. doi: 10.17226/29200.
Page 88
Suggested Citation: "Appendix A: Symposium Agenda." National Academies of Sciences, Engineering, and Medicine. 2025. Gilbert W. Beebe Symposium: AI and ML Applications in Radiation Therapy, Medical Diagnostics, and Radiation Occupational Health and Safety. Washington, DC: The National Academies Press. doi: 10.17226/29200.
Page 89
Next Chapter: Appendix B: Biographies
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