| 2MASS | Two Micron All Sky Survey |
| 4MOST | 4-metre Multi-Object Spectroscopic Telescope |
| AAAC | Astronomy and Astrophysics Advisory Committee |
| AANM | Astronomy and Astrophysics in the New Millennium (2000 astronomy and astrophysics decadal survey report) |
| ACCORD | AURA Coordinating Council of Observatory Research Directors |
| AGN | active galactic nuclei |
| ALMA | Atacama Large Millimeter/submillimeter Array |
| ALTAIR | Access to Large Telescopes for Astronomical Instruction and Research |
| ANTARES | Arizona—NOAO Temporal Analysis and Response to Events System |
| AO | adaptive optics |
| AODP | Adaptive Optics Development Program (NSF) |
| APO | Apache Point Observatory |
| APOGEE | APO Galactic Evolution Experiment |
| ARC | Astrophysical Research Consortium |
| ARCONS | Array Camera for Optical to Near-IR Spectrophotometry |
| ASAS-SN | All-Sky Automated Survey for Supernovae |
| ASM | Adaptive Secondary Mirrors |
| AST | Division of Astronomical Sciences (NSF) |
| ATI | Advanced Technologies and Instrumentation (NSF) |
| ATLAS | Asteroid Terrestrial-impact Last Alert System |
| AURA | Association of Universities for Research in Astronomy |
| BAO | baryon acoustic oscillation |
| BoRG | Brightest of Reionizing Galaxies Survey |
| BOSS | Baryon Oscillation Spectroscopic Survey |
| BPA | Board on Physics and Astronomy (NRC) |
| CAA | Committee on Astronomy and Astrophysics (NRC) |
| CADC | Canadian Astronomy Data Centre |
| CANDELS | Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey |
| CFHT | Canada France Hawaii Telescope |
| CLASH | Cluster Lensing and Supernova Survey with Hubble |
| CPU | central processing unit |
| CTIO | Cerro Tololo Inter-American Observatory |
| DCT | Discovery Channel Telescope |
| DECam | Dark Energy Camera |
| DEIMOS | Deep Imaging Multi-Object Spectrograph |
| DES | Dark Energy Survey |
| DESC | Dark Energy Survey Collaboration |
| DESI | Dark Energy Spectroscopic Instrument |
| DKIST | Daniel K. Inouye Solar Telescope |
| DOE | Department of Energy |
| DPOSS | Digitized Palomar Observatory Sky Survey |
| DR12 | Data Release 12 |
| eBOSS | extended Baryon Oscillation Spectroscopic Survey |
| E-ELT | European Extremely Large Telescope |
| EMIR | Espectrógrafo Multi-objecto InfraRojo |
| EPDS | Extreme Precision Doppler Spectrometer |
| ESA | European Space Agency |
| ESI | Echellette Spectrograph and Imager |
| ESO | European Southern Observatory |
| ESPRESSO | Echelle Spectrograph for Rocky Exoplanet and Stable Spectroscopic Observations |
| FOV | field of view |
| GMACS | GMT wide-field multi-object optical spectrograph |
| GMOS | Gemini multi-object spectrograph |
| GMT | Giant Magellan Telescope |
| GMTO | Giant Magellan Telescope Organization |
| GPI | Gemini Planet Imager |
| GRB | gamma ray burst |
| GSMT | Giant Segmented Mirror Telescope |
| GTC | Gran Telescopio Canarias |
| HEASARC | High Energy Astrophysics Science Archive Research Center |
| HET | Hobby-Eberly Telescope |
| HETDEX | Hobby-Eberly Telescope Dark Energy Experiment |
| HFF | Hubble Frontier Fields |
| HIRES | High Resolution Echelle Spectrometer |
| HST | Hubble Space Telescope |
| HUDF12 | Hubble Ultra Deep Field 2012 |
| IFU | integral field unit |
| INT | Isaac Newton Telescope |
| IPAC | Infrared Processing and Analysis Center |
| iPHAS | INT Photometric H-Alpha Survey |
| iPTF | Intermediate Palomar Transient Factory |
| IR | infrared |
| IRSA | Infrared Science Archive |
| IRTF | Infrared Telescope Facility |
| IVOA | International Virtual Observatory Alliance |
| JWST | James Webb Space Telescope |
| KCWI | Keck Cosmic Web Imager |
| KI | Keck Interferometer |
| KPNO | Kitt Peak National Observatory |
| LAMOST | Large Sky Area Multi-Object Fibre Spectroscopic Telescope |
| LBNL | Lawrence Berkeley National Laboratory |
| LBT | Large Binocular Telescope |
| LBTI | Large Binocular Telescope Interferometer |
| LCOGT | Las Cumbres Observatory Global Telescope |
| LEECH | LBT Exozodi Exoplanet Common Hunt |
| LHC | Large Hadron Collider |
| LIGO | Laser Interferometer Gravitational-Wave Observatory |
| LOSS | Lick Observatory Supernova Search |
| LRIS | Low-Resolution Imaging Spectrometer |
| LSST | Large Synoptic Survey Telescope |
| MARVELS | Multi-object APO Radial Velocity Exoplanet Large-area Survey |
| MAST | Mikulski Archive for Space Telescopes |
| MESA | Modules for Experiments in Stellar Astrophysics |
| MKID | microwave kinetic inductance detector |
| MMT | Multiple Mirror Telescope (former) |
| MOONS | Multi-Object Optical and Near-infrared Spectrograph |
| MOS | multi-object spectroscopy |
| MOSFIRE | Multi-Object Spectrometer for Infra-Red Exploration |
| MREFC | Major Research Equipment and Facilities Construction (NSF) |
| MRI | Major Research Instrumentation |
| MSE | Maunakea Spectroscopic Explorer |
| MSIP | Mid-Scale Innovations Program (NSF) |
| MUSE | Multi-Unit Spectroscopic Explorer (ESO) |
| NASA | National Aeronautics and Space Administration |
| NCSA | National Center for Supercomputing Applications |
| NFIRAOS | Narrow Field Infrared Adaptive Optics System |
| NICMOS | Near Infrared Camera and Multi-Object Spectrometer |
| NIRC | Near Infrared Camera |
| NIRC2 | Near Infrared Camera 2 |
| NIRSPEC | Near Infrared Echelle Spectrometer |
| NN-EXPLORE | NASA-NSF Exoplanet Observational Research |
| NOAO | National Optical Astronomical Observatory |
| NRAO | National Radio Astronomy Observatory |
| NRC | National Research Council |
| NSF | National Science Foundation |
| NuSTAR | Nuclear Spectroscopic Telescope Array |
| NWNH | New Worlds, New Horizons in Astronomy and Astrophysics (2010 astronomy and astrophysics decadal survey report) |
| O/IR | optical and infrared |
| OIR | optical and infrared |
| OSIRIS | Optical System for Imaging and low-Intermediate-Resolution Integrated Spectroscopy |
| OSTP | Office of Science and Technology Policy |
| Pan-STARRS | Panoramic Survey Telescope & Rapid Response System |
| PB | petabyte (= 1 million gigabytes = 1015 bytes) |
| PFS | Prime Focus Spectrograph |
| PI | principal investigator |
| PRC | Portfolio Review Committee |
| PS1 | Prototype Telescope for Pan-STARRS |
| PTF | Palomar Transient Factory |
| ReSTAR | Renewing Small Telescopes for Astronomical Research |
| REU | Research Experiences for Undergraduates (NSF) |
| RMS | radio, millimeter, and submillimeter |
| SALT | Southern African Large Telescope |
| SDSS | Sloan Digital Sky Survey |
| SEEDS | Strategic Exploration of Exoplanets and Disks with Subaru |
| SEGUE | Sloan Extension for Galactic Understanding and Exploration |
| SKA | Square Kilometer Array |
| SLAC | Stanford Linear Accelerator Center |
| SMARTS | Small and Moderate Aperture Research Telescope System |
| SOAR | Southern Astrophysical Research telescope |
| SPHERE | Spectro-Polarimetric High-contrast Exoplanet Research |
| SPMT | San Pedro Martir Telescope |
| SSB | Space Studies Board (NRC) |
| TAC | time allocation committee |
| TAO | Tokyo Atacama Observatory |
| TB | terabyte (=1,000 gigabytes = 1012 bytes) |
| TESS | Transiting Exoplanet Survey Satellite |
| TIO | TMT International Observatory |
| TMT | Thirty Meter Telescope |
| TNO | Trans-Neptunian Object |
| ToO | target of opportunity |
| TSIP | Telescope System Instrumentation Program |
| ugrizy | Set of broadband optical filters from ultraviolet through near-infrared |
| UKIDSS | UKIRT Deep Infrared Deep Sky Survey |
| UKIRT | United Kingdom Infrared Telescope |
| URO | University Radio Observatories |
| USVAO | U.S. Virtual Astronomical Observatory (formerly the National Virtual Observatory |
| UVEX | UV-Excess Survey of the Northern Galactic Plane |
| VISTA | Visible and Infrared Survey Telescope for Astronomy |
| VLA | Very Large Array |
| VLT | Very Large Telescope |
| VO | virtual observatory |
| VVPS | Vision and Voyages for Planetary Science in the Decade 2013-2022 (2011 planetary science decadal survey report) |
| WEAVE | WHT Enhanced Area Velocity Explorer |
| WFIRST | Wide-Field Infrared Survey Telescope |
| WHT | William Herschel Telescope (Canary Islands 4.2-m telescope) |
| WIRO | Wyoming Infrared Observatory |
| WISE | Wide-Field Infrared Survey Explorer |
| WIYN | Wisconsin-Indiana-Yale-NOAO Consortium 3.5-m telescope |
| ZTF | Zwicky Transient Facility |