Integrating Large-Scale Genomic Information into Clinical Practice: Workshop Summary (2012)
Chapter: Appendix A: Workshop Agenda
Integrating Large-Scale Genomic Information into Clinical Practice
July 19, 2011
The Keck Center of the National Academies
500 Fifth Street, N.W.
Washington, DC 20001
MEETING OBJECTIVE
To highlight and identify the challenges and opportunities in integrating large-scale genomic information into clinical practice.
Workshop Assumptions:
• Sequencing technology will advance enough to produce clinically meaningful results.
• Whole-genome sequencing (WGS) will be cost-effective and comparable to other diagnostic tests.
| 8:30–8:35 A.M. | WELCOMING REMARKS |
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Wylie Burke, Roundtable Chair Professor and Chair, Department of Bioethics and Humanities, University of Washington |
| 8:35–8:45 A.M. | CHARGE TO WORKSHOP SPEAKERS AND PARTICIPANTS |
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Bruce Blumberg, Workshop Cochair Institutional Director of Graduate Medical Education, Northern California Kaiser Permanente, The Permanente Medical Group |
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Catherine A. Wicklund, Workshop Cochair |
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| 8:45–9:15 A.M. |
KEYNOTE ADDRESS: THE REALIZATION OF GENOMIC MEDICINE Leslie G. Biesecker |
| 9:15–9:45 A.M. | WORKFORCE |
| Session Moderator: Michael S. Watson, American College of Medical Genetics | |
| 9:15–9:45 A.M. | Requisite Knowledge and Skill Sets for Large-Scale Genomic Data Utilization |
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Bruce R. Korf Wayne H. and Sara Crews Finley Chair in Medical Genetics; Professor and Chair, Department of Genetics; Director, Heflin Center for Genomic Sciences, University of Alabama at Birmingham |
| 9:45–11:50 A.M | ANALYSIS |
| Session Moderator: Debra G. Leonard, Weill Cornell Medical Center | |
| 9:45–10:25 A.M. | Defining Actionable Novel Discoveries, Annotating Genomes, and Re-analysis—A Laboratory Perspective |
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Federico A. Monzon Associate Professor of Pathology, Weill Cornell Medical College/The Methodist Hospital; Director, Research Pathology and Molecular Diagnostics Cores, The Methodist Hospital Research Institute |
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Madhuri Hegde Associate Professor, Department of Human Genetics; Scientific Director, Emory Genetics Laboratory, Emory University School of Medicine |
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| 10:25–11:05 A.M. | Defining Actionable Novel Discoveries, Annotating Genomes, and Re-analysis—A Clinical Perspective |
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Heidi L. Rehm Assistant Professor of Pathology, Brigham and Women’s Hospital and Harvard Medical School; Chief Laboratory Director, Laboratory for Molecular Medicine, Partners HealthCare Center for Personalized Genetic Medicine |
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Michael F. Christman President and Chief Executive Officer, Coriell Institute for Medical Research |
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| 11:05–11:50 A.M. | Discussion with Speakers and Attendees |
| 11:50 A.M. | WORKING LUNCH BREAK |
| 12:05–2:15 P.M. | INTERPRETATION |
| Session Moderator: Muin Khoury, Centers for Disease Control and Prevention | |
| 12:05–1:20 P.M. | Interpretation Models and Context |
| Medical Practice | |
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Robert L. Nussbaum Holly Smith Chair and Professor of Medicine; Chief, Division of Medical Genetics; Member, Institute of Human Genetics; Professor of Neurology, University of California, San Francisco School of Medicine |
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| Pathology | |
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Mark S. Boguski Associate Professor, Center for Biomedical Informatics, Harvard Medical School |
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| Bioinformatics | |
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Nicholas J. Schork Director of Bioinformatics and Biostatistics; Professor, Molecular and Experimental Medicine, The Scripps Translational Science Institute |
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| 1:20–2:15 P.M. | Discussion with Speakers and Attendees |
| 2:15–3:40 P.M. | DELIVERY OF INFORMATION |
| Session Moderator: W. Gregory Feero, National Human Genome Research Institute | |
| 2:15–2:55 P.M. | Innovative Mechanisms for Delivery |
| Integral Delivery Systems and Active Monitoring of Data | |
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Mary V. Relling Chair, Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital |
| Granting Access to Personal Health Information | |
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Robert H. Shelton Founder and Chief Executive Officer, Private Access, Inc. |
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| 2:55–3:40 P.M. | Discussion with Speakers and Attendees |
| 3:40 P.M. | BREAK |
| 3:55–4:25 P.M | ETHICAL AND LEGAL ISSUES |
| Session Moderator: Martha Turner, American Nurses Association | |
| Ethical and Legal Implications for Integrating Large-Scale Genomic Data into Clinical Practice | |
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Henry T. Greely Deane F. and Kate Edelman Johnson Professor of Law; Professor, by courtesy, of Genetics; Director, Center for Law and the Biosciences, Stanford University |
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| 4:25–5:55 P.M | PANEL DISCUSSION: ENVISIONING THE FUTURE |
| Session Moderators: Bruce Blumberg, Northern California Kaiser Permanente | |
| Catherine A. Wicklund, National Society of Genetic Counselors | |
| Panelists: | |
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Mark S. Boguski, Harvard Medical School Michael F. Christman, Coriell Institute for Medical Research Henry T. Greely, Stanford University Madhuri Hegde, Emory University Bruce R. Korf, University of Alabama at Birmingham Federico A. Monzon, Weill Cornell Medical College/ The Methodist Hospital |
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Robert L. Nussbaum, University of California, San Francisco School of Medicine Heidi L. Rehm, Harvard Medical School Nicholas J. Schork, The Scripps Translational Science Institute Robert H. Shelton, Private Access, Inc. |
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| 5:55–6:10 P.M. | CONCLUDING REMARKS |
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Bruce Blumberg, Workshop Cochair Northern California Kaiser Permanente |
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Catherine A. Wicklund, Workshop Cochair National Society of Genetic Counselors |
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| 6:10 P.M. | ADJOURN |
