The U.S. Social Security Administration has requested the National Academies of Sciences, Engineering, and Medicine establish an ad hoc committee to conduct a study to review the latest published research and science and produce a report addressing best practices and community experiences in the management and treatment of sickle cell disease, including hospitalization, parenteral narcotic pain medication, and traditional and alternative therapies and home remedies, their prevalence, efficacy, and side-effects, as well as recent changes or challenges in the provision of such care.